Oncostat is right on with this one. The definition supplied by the snm (Society of Nuclear Medicine) has this definition:
>>Action taken to prevent further changes to a clinical trial database.
NOTE: Locking of a database is done after review, query resolution, and a determination has been made that the database is ready for analysis<<
It has an excellent Powerpoint presentation that explains trials and terminology in detail. Check it out if you have Powerpoint. Great for reference.
www.snm.org/docs/CTN/.../Language%20of%20Clinical%20Trials.ppt